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JWH-018 for sale Pharmacology
JWH-018 is a full agonist of both the CB1 and CB2 cannabinoid receptors, with a reported binding affinity of 9.00 ± 5.00 nM at CB1 and 2.94 ± 2.65 nM at CB2. JWH-018 for sale online USA has an EC50 of 102 nM for human CB1 receptors, and 133 nM for human CB2 receptors. Buy JWH-018 online produces bradycardia and hypothermia in rats at doses of 0.3–3 mg/kg, suggesting a potent cannabinoid-like activity
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At least one case of JWH-018 dependence has been reported by the media. The user consumed JWH-018 daily for eight months. Withdrawal symptoms were more severe than those experienced as a result of cannabis dependence. JWH-018 for sale online has been shown to cause profound changes in CB1 receptor density following administration, causing desensitization to its effects more rapidly than related cannabinoids.
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